measure minute concentrations of NO
Nitric oxide plays an important role in many biological processes; however, natural concentrations are often in the nanomolar range. The Unisense NO microsensor is characterized by a very high sensitivity, which enables you to measure minute concentrations of NO. Combined with a fast response time the Unisense NO microsensor is an excellent research tool for a broad range of tasks.
The sensor can be used equally well for measurements in tissue, air, or liquid, and is applied in a broad variety of research fields where non-destructive, fast and accurate measurements are required. The NO microsensor is designed for research applications within:
- Environmental sciences
- Biomedical sciences
The NO micro- and minisensors are Clark-type sensors measuring the external NO partial pressure. The working principle of the sensor is based on diffusion of NO through a silicone membrane to an NO oxidizing anode, which is polarized against an internal counter cathode. The resulting sensor signal is in the pA range and is measured by a high quality picoammeter e.g. the Unisense Microsensor Multimeter.
Compared to other standard NO sensors the Unisense NO microsensor has an extremely low consumption of max. 935 pmol/hour corresponding to 0,1 %/hour in a 1 mL 0,1uM NO sample.
part numbers and outside tip diameter
- NO-10: 8-12 µm
- NO-25: 20-30 µm
- NO-100: 90-110 µm
- NO-500: 400-600 µm
- NO-MR: 400-600 µm
- NO-NP: 1.6 x 40 mm – needle sensor for piercing
Schreiber,F. et al (2008), Nitric Oxide Microsensor for High Spatial Resolution Measurements in Biofilms and Sediments, Anal.Chem, 1152 – 1158, vol. 80
Aamand,R. et al (2009), Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation, American Journal of Physiology- Heart and Circulatory Physiology, H2068 – , vol. 297
Ettwig,K.F. et al (2010), Nitrite-driven anaerobic methane oxidation by oxygenic bacteria, Nature, 543 – 548, vol. 464